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- Meet a child genius named Sheldon Cooper (already seen as an adult in The Big Bang Theory (2007)) and his family. Some unique challenges face Sheldon, who is socially impaired.
- New Jersey mob boss Tony Soprano deals with personal and professional issues in his home and business life that affect his mental state, leading him to seek professional psychiatric counseling.
- Two brothers follow their father's footsteps as hunters, fighting evil supernatural beings of many kinds, including monsters, demons, and gods that roam the earth.
- Larry David stars as an over-the-top version of himself in this comedy series that shows how seemingly trivial details of day-to-day life can precipitate a catastrophic chain of events.
- A woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- Comedy series following the exploits of Det. Jake Peralta and his diverse, lovable colleagues as they police the NYPD's 99th Precinct.
- The survivors of a plane crash are forced to work together in order to survive on a seemingly deserted tropical island.
- The fractured domestic lives of a nihilistic mad scientist and his anxious grandson are further complicated by their inter-dimensional misadventures.
- A workplace comedy centered around a group of dedicated teachers - and an oblivious principal - in a Philadelphia public school where, despite the odds stacked against them, they are determined to help their students succeed in life.
- A seventeen-year-old aristocrat falls in love with a kind but poor artist aboard the luxurious, ill-fated R.M.S. Titanic.
- The doctors who work in the ER at the County General Hospital in Chicago grapple with ups and downs in their personal and professional lives while trying to give apt medical care to their patients.
- Set 97 years after a nuclear war destroyed civilization, when a spaceship housing humanity's lone survivors sends 100 juvenile delinquents back to Earth, hoping to repopulate the planet.
- A young Clark Kent struggles to find his place in the world as he learns to harness his alien powers for good and deals with the typical troubles of teenage life in Smallville, Kansas.
- A chronicle of the lives of a dysfunctional family who run an independent funeral home in Los Angeles.
- Half-brothers Lucas and Nathan Scott trade between kinship and rivalry both on the basketball court and in the hearts of their friends in the small, but not so quiet town of Tree Hill, North Carolina.
- Bob Belcher runs a struggling burger shop with his wife and three children.
- Secrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- In the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- Inside the lives of staffers in the West Wing of the White House.
- Marty McFly, a 17-year-old high school student, is accidentally sent 30 years into the past in a time-traveling DeLorean invented by his close friend, the maverick scientist Doc Brown.
- A group of ambitious misfits try to escape the harsh realities of high school by joining a glee club headed by a passionate Spanish teacher.
- The story of a group of British teens who are trying to grow up and find love and happiness despite questionable parenting and teachers who would rather be friends (and lovers) than authority figures.
- An emotionally troubled young woman sets out to exact revenge against the people who wronged her father.
- A troubled youth becomes embroiled in the lives of a close-knit group of people in the wealthy, upper-class neighborhood of Newport Beach, Orange County, California.
- This ABC show takes place in Jenkintown, Pennsylvania in the 1980s and follows the lives of a family named The Goldbergs.
- The story behind Detective James Gordon's rise to prominence in Gotham City in the years before Batman's arrival.
- A New York City police officer tries to save his estranged wife and several others taken hostage by terrorists during a Christmas party at the Nakatomi Plaza in Los Angeles.
- A friendly guy from the Midwest tries to fit into a tough L.A. neighborhood.
- A straight-laced propane salesman in Arlen, Texas tries to deal with the wacky antics of his family and friends, while also trying to keep his son in line.
- An eight-year-old troublemaker, mistakenly left home alone, must defend his home against a pair of burglars on Christmas Eve.
- A ne'er do well wins $100,000 in the lottery and decides to right all the wrongs from his past with his newfound realization!
- A young, devout Catholic woman discovers that she was accidentally artificially inseminated.
- Smart but wholesome Betty embraces her unique appearance and independent attitude in the cutthroat world of New York fashion.
- Two young women waitressing at a greasy spoon diner strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
- Melinda Gordon, a newly married woman, possesses the gift of communicating with the dead. With her best friend Andrea's assistance, she helps the earthbound spirits to find peace and cross over.
- The series focuses on a single Harley Quinn, who sets off to make it on her own in Gotham City.
- A Kansas family relocates to Beverly Hills, where their two children adapt to the infamous social drama of West Beverly Hills High.
- The story of the drama surrounding a family's adult siblings.
- A mysterious pill that enables the user to access 100% of his brain's abilities transforms a struggling writer into a financial wizard, but it also puts him in a new world with many dangers.
- A group of young offenders doing community service gets struck by lightning during a storm and start to develop superpowers.
- Follows the lives and tragedies of rising and fading country music stars in Nashville, Tennessee.
- Follows four friends and their antics during their final years of school.
- A hip-hop mogul must choose a successor among his three sons who are battling for control over his multi-million dollar company, while his ex-wife schemes to reclaim what is hers.
- Clark Kent builds his secret Superman identity and embraces his role as the hero of Metropolis, while sharing adventures and falling in love with Lois, a star investigative journalist, who also takes Jimmy Olsen under her wing.
- Greg Heffley is a 12 year old who is fresh out of elementary and transitions to middle school, where he has to learn the consequences and responsibility to survive the year.
- Now settled in Genovia, Princess Mia faces a new revelation: she is being primed for an arranged marriage to an English suitor.
- In 1931 Paris, an orphan living in the walls of a train station gets wrapped up in a mystery involving his late father and an automaton.
- RuPaul searches for America's next drag superstar.
- This Chicago-set sitcom follows the intertwined lives of six young urbanites trying to learn the ropes of adulthood. Through breakups and whatever other curve-balls life throws them, the pals stick together.
- A semi-anthology series that centers on characters being terrorized by a serial killer in different locations, including a university and a hospital.