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- Medical examiner Megan Hunt's unique approach to solving crimes puts her at odds with her superiors.
- A family takes in a formerly institutionalized teen savant who is missing standard human behaviors such as anger, joy, and love.
- Ten people are invited to a paradise island in the Caribbean by a mysterious person, and each of them has committed a murder in their past.
- There were 10 people at a hotel on an island in the West Indies. When two police officers arrive they find it in disarray and empty of people. Eight days prior when people arrived on the island to check in, no manager could be found.
- No more network, and their helicopter was sabotaged; Impossible to leave the island where a voice has accused them of murder; and soon one of them is found dead and it can't be an accident.
- Xavier suspects Eddy of being the mysterious killer who's doing away with them; he ties him to a tree; Eddy remembers things best left unsaid in his past.
- While drinking water becomes a terrible problem, Victoria suspects Kelly and she drugs her, ties her up and throws her in a bath tub where she nearly drowns; Xavier is poisoned by a lethal gas.
- Three of the forced guests of the island's past: a surgeon who tried to outshine her father and caused her patient's death, a selfish psychiatrist/guru and his miserable chauffeur, a student who slept with her professor..
- And then there were three: two of them fall in love but both have something on their conscience and besides: they suspect each other of being the criminal; the police arrive on the island--will they save the surviving guests?
- A female jogger is found floating in the Schuylkill River. Dr. Megan Hunt teams up with her partner, medical investigator and former cop Peter Dunlop, under the watchful eye of their boss, Chief Medical Examiner Dr. Kate Murphy, who is very aware of Megan's gifted but polarizing work style. Megan's colleagues, Dr. Ethan Gross and Deputy Chief Medical Examiner Dr. Curtis Brumfield, must find their own way to work alongside the new medical examiner. Megan's investigation takes her out in the field where she meets old-school cop Detective Bud Morris, who is exasperated by Megan's tenacity and bull-headedness. But his partner, Detective Samantha Baker, possesses a quiet respect for Megan's input, even if Morris doesn't. Meanwhile, as she's is trying to solve the female jogger's death, Megan has to solve a personal puzzle of her own -- what is the perfect present for her daughter's 12th birthday?