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- Meet a child genius named Sheldon Cooper (already seen as an adult in The Big Bang Theory (2007)) and his family. Some unique challenges face Sheldon, who is socially impaired.
- Larry David stars as an over-the-top version of himself in this comedy series that shows how seemingly trivial details of day-to-day life can precipitate a catastrophic chain of events.
- A mockumentary on a group of typical office workers, where the workday consists of ego clashes, inappropriate behavior, and tedium.
- A woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- Three different, but related, families face trials and tribulations in their own uniquely comedic ways.
- Follows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- A hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- A newly sober single mom tries to pull her life together in Napa Valley while dealing with her wayward mother.
- A hit man from the Midwest moves to Los Angeles and gets caught up in the city's theatre arts scene.
- A comedy about the experiences of a group of girls in their early 20s.
- Covert black ops and espionage take a back seat to zany personalities and relationships between secret agents and drones.
- Four people and their otherworldly frienemy struggle in the afterlife to define what it means to be good.
- The comical everyday life of sports columnist Ray Barone and his dysfunctional family.
- The daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- Follows the struggle of Richard Hendricks, a Silicon Valley engineer trying to build his own company called Pied Piper.
- The escapades of Stan Smith, a conservative C.I.A. Agent dealing with family life, and keeping America safe.
- Deliveryman Doug Heffernan has a good life: He has a pretty wife (Carrie), a big television, and friends with which to watch it. Then Carrie's goofy, annoying father Arthur moves in with them.
- Liz Lemon, head writer of the sketch-comedy show "TGS with Tracy Jordan", must deal with an arrogant new boss and a crazy new star while trying to run a successful television show without losing her mind.
- When a suburban mother turns to dealing marijuana in order to maintain her privileged lifestyle after her husband dies, she finds out just how addicted her entire neighborhood already is.
- Gay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- A writer tries to juggle his career, his relationship with his daughter and his ex-girlfriend, as well as his appetite for beautiful women.
- Two young women waitressing at a greasy spoon diner strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
- A family comedy narrated by Katie, a strong-willed mother, raising her flawed family in a wealthy town filled with perfect wives and their perfect offspring.
- Three incoming freshmen attending Midwestern college football powerhouse Blue Mountain State must quickly adapt to college life and juggle football, girls, classes and nonstop hazing.
- An overprotective father is obsessed with becoming a principal and competes against the popular vice principal. However, something happens that makes them work together to save the day.
- Two couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- A drug-addicted nurse struggles to find a balance between the demands of her frenetic job at a New York City hospital and an array of personal dramas.
- A series centered around a group of football players and their families, friends and handlers.
- A couple meets at an Overeaters' Anonymous meeting.
- Follows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- A family man struggles to gain a sense of cultural identity while raising his kids in a predominantly white, upper-middle-class neighborhood.
- This Chicago-set sitcom follows the intertwined lives of six young urbanites trying to learn the ropes of adulthood. Through breakups and whatever other curve-balls life throws them, the pals stick together.
- Follows the awkward experiences and racy tribulations of a modern-day African-American woman.
- After a family scandal leaves Mel, a local politician, in charge of her niece and nephew, she hires a man named Joe to become the family's male nanny, or "manny."
- A 20-something bachelor bartender becomes an unlikely parent when an ex-girlfriend leaves a baby girl on his doorstep.
- Ex-baseball-player Charlie is an anger-management therapist who has small-group sessions at home, an OCD teen daughter, an ex-wife, and a sex-buddy/therapist.
- A well-off young tech entrepreneur hires a feisty young food blogger to be his personal chef.
- The life of Louie C.K., a divorced comedian living in New York with two kids.
- The personal and professional misadventures of an opinionated but beloved woman working as a television journalist.
- Tessa Altman is used to the big city, but when her dad moves her away, she has to adapt to her new suburban life in Chatswin.
- Jeff, a famous children's television icon, struggles to retain his sanity as his family falls apart.
- Conan O'Brien and his co-host Andy Richter discuss current news topics and interview celebrities and personalities.
- A comedy that explores the private lives of unique New York individuals through a common thread: their weed deliveryman.
- Lone-wolf detective Angie Tribeca and a squad of committed LAPD detectives investigate the most serious cases, from the murder of a ventriloquist to a rash of baker suicides.
- A part-improvised comedy about a couple bringing up their three young children.
- A posh single mother struggles to raise her two daughters alone in 1970s Los Angeles while she deals with own life along with her two best friends. Inspired by the childhood of reality star Kyle Richards.
- Jimmy Fallon hosts the Tonight Show and interviews celebrities, plays games with them and has a musical or comedic guest perform.
- A New York comic is forced to make a new start for himself after his wife leaves him.
- A couple goes through a long, drawn-out divorce.
- Journalist Ozzie Graham is skeptical when he investigates a support group for oddballs who think they have been abducted by aliens -- yet the more he learns, the more confused, intrigued, and seduced he becomes.