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- DirectorTony PhelanStarsEllen PompeoSandra OhJustin ChambersAs the hospital inches closer to finding a buyer, many of the doctors don't like the new changes being made, causing the crash survivors to consider a crazy idea. Meanwhile, April's relationship with Matthew progresses and she asks Jackson for advice.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglThe first shift for new surgical interns Meredith, Cristina, Izzie, George, and Alex proves eventful and backbreaking.
- DirectorAnita W. AddisonStarsAnthony EdwardsGeorge ClooneySherry StringfieldDr. Kayson becomes Lewis' patient.
- DirectorJoe ChappelleStarsDavid CarusoEmily ProcterAdam RodriguezA Colombian importer is found with a 'necklace bomb' around his neck. The bomb explodes, killing a bomb squad officer, Al, who is Horatio's friend.
- DirectorJames FrawleyStarsEllen PompeoSandra OhKatherine HeiglCristina is still in her slump and turning mean, Izzie finally confronts Ava/Rebecca, and Meredith's anger with her therapist is challenged by a patient with a Cinderella story.
- DirectorRobert Duncan McNeillStarsChad Michael MurrayJames LaffertyHilarie Burton MorganNathan must choose which parent to live with after Dan and Deb's divorce. Dan forces Nathan to make the decision by threatening to reveal Deb's darkest secrets in court unless Nathan chooses him. Meanwhile, Lucas meets a beautiful stranger who challenges his perceptions of life since Lucas' car accident.
- DirectorFélix Enríquez AlcaláStarsAnthony EdwardsNoah WyleLaura InnesDr. Susan Lewis arrives, looking for work in the Chicago area again. Greene hires her, over Weaver's objection. Chen nervously attends a risk management review, accompanied by the unforgiving Weaver, to discuss a patient who recently died under Chen's supervision.
- DirectorJohn David ColesStarsEllen PompeoSandra OhKatherine HeiglMeredith worries she did something wrong during a heart bypass, an error in a past procedure is discovered, putting a staff member's conduct under scrutiny, while a party thrown by Izzie to introduce her boyfriend becomes a fiasco.
- DirectorMichael WaxmanStarsNick GehlfussYaya DaCostaTorrey DeVittoThe grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.
- DirectorAmi Canaan MannStarsNick GehlfussYaya DaCostaTorrey DeVittoDoctors Rhodes and Downey have a disagreement over a patient's emergency heart surgery.
- DirectorTara Nicole WeyrStarsNick GehlfussYaya DaCostaTorrey DeVittoConnor is forced to confront his past when he takes on the case of a close family friend who's been impaled by glass shards.
- DirectorDonald PetrieStarsNick GehlfussYaya DaCostaTorrey DeVittoIn the aftermath of a movie theater shooting, the doctors work to treat the victims while Sharon tries to keep the press at bay.
- DirectorNick GomezStarsNick GehlfussYaya DaCostaTorrey DeVittoAs Doctors Rhodes and Zanetti race against the clock to save a fallen member of Firehouse 51, the case of a woman clinging to life is discovered to be similar to those of other patients.
- DirectorFred BernerStarsNick GehlfussYaya DaCostaTorrey DeVittoDoctors Rhodes and Downey set aside their differences to operate on a 9/11 hero with pulmonary fibrosis.
- DirectorJean de SegonzacStarsNick GehlfussYaya DaCostaTorrey DeVittoDr. Halstead jeopardizes his career when he goes against a family's orders and revives a terminally ill cancer patient.
- DirectorJann TurnerStarsNick GehlfussYaya DaCostaTorrey DeVittoSharon must decide whether to put her job on the line for a patient in need.
- DirectorMichael WaxmanStarsNick GehlfussYaya DaCostaTorrey DeVittoSharon is visited by the Department of Homeland Security regarding two airplane stowaways who are brought to the hospital with major injuries.
- DirectorHolly DaleStarsNick GehlfussYaya DaCostaTorrey DeVittoNurse Lockwood is arrested for refusing to take blood from a suspected DUI patient without his consent.
- DirectorMichael WaxmanStarsNick GehlfussYaya DaCostaTorrey DeVittoDr. Halstead (Nick Gehlfuss) and Sharon Goodwin (S. Epatha Merkerson) deal with a husband intent on harvesting his recently deceased wife's eggs, but soon discover some vital information that surprises everyone. Dr. Charles (Oliver Platt) is brought in by Dr. Choi (Brian Tee) to aid a patient who is trying to remove his own arm from his body because he feels like it doesn't belong. Nurse Sexton (Yaya DaCosta) befriends the father of a child who is rushed into the hospital after swallowing magnets - a situation that Dr. Rhodes (Colin Donnell) and Dr. Manning (Torrey DeVitto) are concerned could present dangerous complications. Meanwhile, Sarah Reese (Rachel DiPillo) finally learns about where she will do her residency, but has last-minute second thoughts.
- DirectorDonald PetrieStarsNick GehlfussYaya DaCostaTorrey DeVittoDoctors Choi and Charles are left with a patient claiming his heart is pounding in his head, while Dr. Manning suspects that a young boy with a broken wrist has deeper problems.
- DirectorFred BernerStarsNick GehlfussYaya DaCostaTorrey DeVittoApril and Dr. Halstead treat an alcoholic homeless man with a broken leg.
- DirectorMichael WaxmanStarsNick GehlfussYaya DaCostaTorrey DeVittoDr. Rhodes treats Dr. Downey while Dr. Halstead receives clarity from Goodwin.
- DirectorArthur W. ForneyStarsNick GehlfussYaya DaCostaTorrey DeVittoThe doctors of Chicago Med experience various changes.
- DirectorDavid RodriguezStarsNick GehlfussYaya DaCostaTorrey DeVittoDr. Choi mentors a Navy corpsman, while two cases involving sick babies may have a connection.
- DirectorStephen CraggStarsNick GehlfussYaya DaCostaTorrey DeVittoDr. Charles' daughter deals with cases of a rare infection when she joins the epidemiology department.