- Spends every Thanksgiving with Helen Hunt.
- When he was a teenager, studied ballet with his childhood friend Eric Stoltz in Santa Barbara, California, so that "they could meet girls."
- When Edwards received a large bonus from the producers of ER, he donated a large portion of it to the Santa Barbara Junior High School for the renovation of its theater, later named in honor of his middle school drama teacher, Marjorie Luke. The Theater is now home to numerous plays and performances not only for the Junior High School, but also for the entire community.
- His grandfather designed Walt Disney Studios in the 1930s.
- His ex-wife, Jeanine Lobell, is a respected & renowned make-up artist who also founded the Stila cosmetics line.
- Was approached by Michael Crichton (author of "Jurassic Park") and producer John Wells to star in a two-hour pilot called ER (1994) after playing a lawyer in The Client (1994).
- Owns his production company, Aviator Films
- Plays basketball with friend George Clooney, who also co-starred with him on ER (1994).
- Is currently on the Board of Cure For Autism Now Foundation.
- Had a relationship with Meg Ryan [1986-1987].
- Driver of Pace Car at 84th Indianapolis 500, May 28, 2000.
- Has four children: Son Bailey (born June 1, 1994), daughters Esme and Wallis born (September 1, 2000) and daughter, Poppy (born March 15, 2002) with wife Jeanine Lobell.
- His parents wouldn't allow him to watch prime-time TV as a teenager.
- Is an honorary board member of Access Theatre, a repertory acting company comprised of disabled artists. A documentary he directed about this group has received several awards and is being distributed in high schools around the United States.
- Is good friends with Aimee Mann and Natalie Portman.
- Had watched every single Gene Kelly musical, which led him to becoming "a song and dance man".
- Attended Santa Barbara Jr. High with Kathleen Wilhoite who co-starred in several episodes of ER (1994) as "Chloe Lewis".
- (1986 - 88) Graduated from University of Southern California with a BA in drama
- Is a big fan of South Park (1997).
- Grew up and went to school with Eric Stoltz and Linus Huffman.
- Named as "Favorite Male Television Performer in a Series" by the People's Choice Awards.
- Moved to Manhattan, New York, in 2002
- Is a big fan of race car driving.
- Named "The Sexiest Man" in a prime-time series [1997].
- Anthony's father was of English, Irish, Scottish, and one quarter Spanish-Mexican, ancestry. Anthony's maternal grandfather was German, and Anthony's maternal grandmother was born in China, to German parents.
- Has a cat named Nitro.
- Attended San Marcos High School in Santa Barbara, California and graduated in 1980 (as stated on wall of fame plaque in auditorium).
- Was raised in "The Riviera", Santa Barbara's answer to Beverly Hills. His family belonged to the Riviera Country Club.
- As a teenager, he collected James Taylor's and Styx's tapes/records.
- Has expressed regrets about appearing in Top Gun (1986) because he feels the film contributed to a militaristic and warmongering mindset that he is personally opposed to.
- His maternal grandfather, Kem Weber (Karl Emanuel Martin Weber), who was born in Berlin, was a prominent furniture/industrial designer, teacher, art director, and architect, and his maternal great-grandfather, Alfred Forke, was a Sinologist and UC Berkeley professor.
- Nominated for best actor by the Viewers for Quality Television.
- At 16, he appeared in dozens of plays
- Best known by the public for his starring role as Dr. Mark Greene on [ER (1994)].
- Nominated as "Best Actor" by Cable Ace for his part in Sexual Healing (2006).
- Honda Civic was his very first car.
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