- She shaved her head for the role of Lieutenant Ilia in the film Star Trek: The Motion Picture (1979). At first, she shed tears over the haircut, but smiled after the finishing powder was applied to her scalp and her facial features were more defined by Fred Phillips.
- She was temporarily blinded during the scene in Star Trek: The Motion Picture (1979) which Lieutenant Ilia was taken by V'Ger, a scene which required her to keep her eyes wide open while being bombarded by intense light. This resulted in a form of flash blindness from which she soon recovered.
- Underwent heart bypass surgery in 1983. Died of a heart attack on August 18, 1998, aged 49.
- Was Femina Miss India 1965. She published a coffee table book about the history of the Miss India pageant titled "Pride of India".
- An action figure doll was modeled after her Star Trek character, Lieutenant Ilia. Also, a character in Borderland (2004) is named after her.
- In 1965, she entered that year's Miss Universe contest held in Miami Beach, Florida. She was not as lucky at Miss Universe as she failed to be in the top 15, and the contest was won by 18-year-old Apasra Hongsakula of Thailand.
- Was seriously injured in an automobile accident in Germany in 1980, which left her with a large scar on her head.
- Auditioned for the female lead role in the James Bond film Octopussy (1983), which went to Maud Adams.
- One of three actors from India to appear in the Star Trek franchise. The others were: Padma Lakshmi (from Precious Cargo (2002)) and Vijay Amritraj (USS Yorktown captain in Star Trek IV: The Voyage Home (1986)).
- She is also one of two actors (in general) from the Star Trek franchise to appear in MacGyver (1985). The other was John Anderson.
- Born the same day as fellow "Star Trek" veteran Avery Brooks.
- Had starred in the shelved film "Tum Salamat Raho" opposite Shetty (famous villain and fight master). This would have been Shetty's first film as a lead actor.
- Best known by the public (and by many sci-fi fans) for her role as Lieutenant Ilia in Star Trek: The Motion Picture (1979).
- Khambatta's husband, Naren Parekh, had a detective agency in Toronto, Canada.
- Was to debut opposite Salim Khan in the B grade film Watan. This was in 1965. The film was eventually shelved.
- Leela Chitnis's son, actor/producer Manavendra Chitnis, produced a film, shot exclusively in New York in 1976 and titled 'New York, New York'. It starred Khambatta and Sanjeev Kumar. The two actors had shot a song riding a bike in Central Park in New York. The film was shelved for financial reasons.
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