She was nicknamed "The O. Henry Girl" because she appeared in so many two-reel films based on O. Henry short stories for Vitagraph.
She lost much of her fortune in the 1929 stock market crash.
Her first big break at Vitagraph came when Alice Joyce noticed Agnes' resemblance to herself and had her cast in a minor part as her sister in Richard the Brazen (1917).
Like Gloria Swanson, she was discovered while on tour at Essanay's Chicago studios.