- Vana is the daughter of actor Van Heflin and actress Frances E. Neal. She is the sister of actress Kate Heflin and Tracy Heflin. Her cousins are actress Marta Heflin, director Jonathan Kaplan and actress Mady Kaplan. Her daughter is actress Eleanor O'Brien.
- Cast twice by Gus Van Sant, first in My Own Private Idaho (1991) and again in Elephant (2003). Both films were shot in O'Brien's home of Portland, Oregon.
- Niece of Frances Heflin and Sol Kaplan.
- Vana is a well-known stage actress in Portland, Oregon.
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