When Dexter's principal calls Francine, Francine starts acting as if he's hung up on her before he's even said goodbye.
When Cuddles takes Francine out on a shopping spree to forget her alcoholic troubles, they pass by Todd Tomorrow with a white Pontiac Trans Am. He sports a pair of sunglasses, where the cameraman's reflection is visible.
In the opening scene in the living room, as the Fishpaws are arguing, a boom mic is visible. This was corrected for later DVD releases.