The opening to the show was mostly the same as the opening on Fox's Merrie Melodies Starring Bugs Bunny & Friends. The exceptions were a new jazzy soundtrack over the animation and the That's Warner Bros! logo replacing the one for Merrie Melodies. Unlike Merrie Melodies, not all That's Warner Bros! episodes featured a Bugs Bunny cartoon.
After the first season, the show's title was changed to The Bugs n' Daffy Show and given a new opening. The format remained the same, but each cartoon's opening credits were replaced with a still title card.