James Gunn wrote the screenplay in just two weeks. and the screenplay is what got him every bit of work hes had in Hollywood since. Paget Brewster adds that the film has gotten her no work at all. Gunn specifies that it was the screenplay that led to more work not the actual film.
Rob Lowe taught James Gunn "the extras game" where you identify nameless players by which celebrity they resemble. He went on to use that in his script for Dawn of the Dead (2004) with the guys on the roof top calling out zombies by lookalike name.
James Gunn lived in Jamie Kennedy's guest house when he first moved to Los Angeles as the actor was a big fan of the script, but they would get into "heated battles" non-stop during production. They're still friends.
James Gunn gave the script to his brother Sean who passed it to Jamie Kennedy who shared it with his manager who then took on Gunn as a client. "Within a month I had a deal to write Spy vs Spy for Warner Bros."
On the commentary they mention Michael Weatherly (Dark Angel, 2000-2002) who Gunn says was engaged and then not engaged to Jessica Alba. "Oh, thank god," says Brewster. "That broad, ugh." Gunn wonders what that's about saying she's a "nice" woman, but Brewster replies "Have you had dinner with her? If you ever wanna punish yourself for some unforgivable sin, sit down and have dinner with Jessica Alba." She later adds that Weatherly became "a dick when they were dating." This is a great commentary track.