- Dr. Anton Rudolph: You have no idea what you're up against.
- Bart Parker: You don't know my men.
- Dr. Anton Rudolph: This is not some garden snake you're going after. We are talking about a perfect killing machine. A 129-foot all-terrain vehicle capable of speeds exceeding 50 miles an hour with skin that can deflect an antitank round, enhanced night vision and a voracious appetite for human flesh. It will slaughter your men before they have a chance to blink.
- Dr. Anton Rudolph: Already I had fixed my gaze upon him and he rose upright with breast in countenance, as if he entertained some great scorn of hell.
- Kristin: Look, let's just wait it out. Sooner or later it's bound to get hungry.
- Dr. Anton Rudolph: You must understand, it's still basically a snake. Even at its size, it can go without a month without feeding right outside that door.
- John Cooper: There's not enough food in here to wait that long. And if it did decide to leave, where do you think it would go?
- Kristin: Ruby. Oh, my God. The whole town is like an all-you-can-eat special.
- John Cooper: And I sure don't want to wait around here to see what's gonna happen. So what do you say? How about it?
- Theresa: Well, I say we kill the motherfucker.
- John Cooper: [to his brother] No time to explain, Bri. Let's just say there's this little...
- Kristin, Greg Larsen, Theresa: LITTLE?
- John Cooper: Big, big thing after us.
- Theresa's Shirt: I helped kill a giant python and all I got was this lousy t-shirt!