Screenwriter Charlie Kaufman received a great deal of acclaim for his "Being John Malkovich" script, but while that film contained many quirky and inventive ideas, the plot fell apart in the third act, making for an ultimately unsatisfying experience. The same can be said for his second produced script, "Human Nature," which is chock-full of good ideas but ultimately unravels. Kaufman is clever and a jokester, he's just not much of a scenarist.
On the up side, there's a lovely performance by Patricia Arquette, who's not afraid of any of the many bizarre turns her character goes through, and director Michel Gondry (who has made terrific videos for Bjork and others) does the best that he can with the script. (Although those CG mice are pretty lame once they are set free.)
Not an unalloyed success, but some elements here definitely work. Too bad they don't all come through.