The new chief of medicine turns out to be as callous as Dr. Kelso, J.D. gives up on his intern class after they let him down, and Eliot is too self-absorbed to realize that Keith is still hurt from their breakup.
Cole reveals Drew's most embarrassing moment when Drew beats him out as the speaker at the white coat ceremony, while Denise turns to Turk and Eliot for more relationship advice.
Lucy struggles to acknowledge that she likes Cole, Dr. Cox and Dr. Turk's rivalry is put aside for a gravely ill patient, and Denise plays a prank on the security guards at the hospital.
J.D. and Elliot's sex life disappears as they get closer to the birth of their child, Dr. Cox refuses to sign his will after a patient dies, and Lucy is terrified of cutting a familiar cadaver for a group exam.
Dr. Cox tries to find out which member of Lucy's study group cheated on a test, Drew gets in trouble when he tells Denise he loves her and then makes the situation worse, and a patient irrationally chooses surgery over treatment.
Turk is jealous when he is upstaged by a talented visiting surgeon, and the study group falls apart when Dr. Cox removes Drew from the group so that Drew can shadow him.
Cole is depressed when nobody but Lucy shows up for his melanoma procedure, Dr. Kelso loses some of personal independence after some tests, and Drew discovers that Dr. Mahoney has the same personality as Dr. Cox.