The first episode of the sixteenth season, shot in June 2008 and scheduled to air in early September, revolved around a big plane crash in Madrid-Barajas. Late in august 2008, a plane crashed in Madrid-Barajas leaving a death toll of 154. The network decided not to air that episode and start the season with the second episode.
Amaia Lizarralde was pregnant during filming of Season 6, but her role was not adjusted to suit her condition.
The set of "Hospital Central" is usually used in other series of Telecinco as Los Serrano (2003) or El comisario (1999).