After a chemical accident transforms her into a half-human half-plant being, Pam Isley takes the name Poison Ivy and sets out to destroy Gotham's environmental polluters.
After a physical trauma causes him to forget he's The Batman, Bruce Wayne finds himself kidnapped by Penguin. Batgirl rescues the "helpless" amnesiac billionaire but is captured herself.
Gearhead, a part-cyborg adrenaline junkie, rides into Gotham in a souped-up racer. With the ability to take control of cars with his nano-technology, Gearhead is out to commit a series of crimes for thrills.
After getting his hands on Bane's steroid apparatus, Joker uses it to bulk up to monstrous proportions. As Joker toys with the city with his superhuman strength, The Batman and Batgirl must find a way to defeat this unstoppable force.
When a pair of leopards is stolen by Joker, The Batman and Batgirl form an uneasy alliance with Catwoman who is determined to save the rare animals from being hunted.
Toymaker Cosmo Krank seeks revenge against Bruce Wayne after the billionaire successfully leads a campaign to remove his unsafe toys from store shelves.
The Digitally Advanced Villain Emulator, or D.A.V.E., is an artificially intelligent computer program made up of the combined psychological profiles of the most diabolical criminals committed to Arkham Asylum.