The character Roger Wilco ranked #5 in Computer Gaming World's November 1996 listing of the 15 most memorable game heroes.
One of the graffiti messages in the restroom at Vohaul's asteroid is "Ken was here! (So was Al, but we had to repaint afterward.)" - clearly referring to Ken Williams, the CEO of Sierra On-Line and Al Lowe.
Like in Space Quest, Chapter 1: The Sarien Encounter (1986), after the introduction the player is requested to enter his name. The default name is Roger Wilco, in case the player presses "Enter" instead of typing any name.
When typing "get condom" from Roger's locker, the game message is: "Sorry. The used Nancy Reagan autographed "Just Say No" condom had to be removed for the shipping version".
When selecting "About SQ2" from the game menu, the game message is "Space Quest was designed and created by Mark Crowe and Scott Murphy". When selecting it after Roger dies, the message says further "We hope you're not looking for someone to blame just because you died".