The movie was lit for black-and-white, but shot in color. The film was finally rendered in black-and-white, wide-screen, 16x9.
The cast and crew had to surprisingly shoot around nudists walking in the background at a beach location, because the spot was an "unofficial" nude beach near Santa Barbara.
Dr. Lazaroff's laboratory was a real, working lab, at a Burbank facility (no longer in business) called Tri-Ess Sciences.
In William Winckler's early drafts of the screenplay, the Frankenstein monster spoke a lot. However, this extensive dialog was cut, in order to give horror fans a Frankenstein monster they preferred... a creature sympathetic, but mostly silent and menacing.