Nick and Sara conclude that a collection of Beatles records have been stolen. Later in the lab, Hodges says "I've been working like a dog". This is possibly a reference to the golden retriever in the episode, but it is also a lyric from the Beatles sound-track album "A Hard Day's Night".
This is one of the few new episodes of any series which aired on a holiday. It aired on Thanksgiving night 2005.
When examining the dog, the vet says "let's take a look at our Cujo". Cujo is the titular character in the 1981 psychological horror novel by Stephen King about a rabid dog. The novel was made into a film in 1983.
Actress Jessica Collins is the first of two actresses to appear on CSI with the same name. The second actress is best known as Natalie Davis aka The Miniature Killer.