This was the first episode to feature Eliza Schneider providing the voices for some of the female characters following Mary Kay Bergman's death.
As a way of saving time and money, frames from Mr. Hankey's Christmas Classics (1999) are used; for instance, the scan of the colon infection is the x-ray scan from Mr. Hankey's intro song. Also, Jesus has a picture of himself and Santa performing their duet.
This is the first appearance of God.
Originally, Season 3 was planned to end with Mr. Hankey's Christmas Classics (1999). However, Comedy Central wanted to make an episode regarding the arrival of the new millennium (The Year 2000) because every other show was producing Y2K episodes.
Jesus' home address is 80122. The zip code is from Littleton, Colorado where the creators grew up.