The movie rights to Largo Winch were first sold 20 years prior to this film to producer Serge Silberman, who's ambition was to create a franchise that could rival James Bond's. He however died before being able to work on the project.
Jean Van Hamme declared that though Tomer Sisley doesn't look like Largo Winch as drawn by Philippe Francq, he nevertheless resembles the one depicted in the novels, which preceded the comic book series.
Jérôme Salle first thought of making a Largo Winch movie six years before this film, and acquired the rights after completing Anthony Zimmer (2005)
Two Brazilian twin brothers who were extras on the film sold their car to buy a plane ticket and continue the shoot in Hong Kong.
The film is mainly based on the first two albums of the comic book series, with elements of the next two also included.
Tomer Sisley learned Serbian for the film and performed a lot of his own stunts.
The Hong Kong action scenes were shot without official authorization, with a small crew looking out for the police.
Though in the film, the W Group's headquarters are in Hong Kong, in the comic book they are located in New York.
The part of the film set in Brazil in the movie was set in Turkey in the comic book.
In the film, Nerio and later Largo stay in a yacht off the coast of Hong Kong. In the comic book, they stay in a penthouse at the top of the W Group building.
In the comic book, Nerio is killed by being thrown off the roof of the Winch building. In the movie he is drowned.
In the movie, it is told that Nerio was born poor and made all his wealth by himself. In the comic book Nerio's father was already billionaire.
In the comic book, Largo is raised by a Liechtensteinian couple. In the movie the couple is Croatian.