It was meant to be the series finale, but accidentally aired before the last five episodes.
After the production of They Got Chops/Poetic Injustice/Comedy of Feathers, this is the three last times when Dexter is not is his laboratory, and Mandark takes over the opening theme from Dexter's Laboratory to Mandark's Laboratory.
Dexter made a fourth wall joke when he said "Well, like I always say, if you can't play with the big dogs, stay on the porch." and the words THE END appear on screen and he says his last words "Hey! What's this going on? I'm trying to wax poetic here!"
During the last produced episode of the series, Mandark was trying to activate a machine by pressing a button on a remote but it didn't work until Dexter plugged in the machine which made Dexter's Laboratory appear in green letter the way it does in the theme song, this was a reference to the theme song.
This is the last episode produced in 2003.