The story of Lisa and Juliet is a reference both to the Parker-Hulme murder in 1954, New Zealand, and also to Peter Jackson's Heavenly Creatures (1994), a film based on the same murder.
The final episode produced and broadcast in standard definition before moving to high-definition for the rest of the series, and also the last episode to use the original intro that began with season 2.
Fall Out Boy performed the theme to this episode. There was a character named Fallout Boy in Radioactive Man (1995) which is actually who the band named themselves after.