Lovelace claimed that Deep Throat (1972) made $600 million at the box office. In his review of Inside Deep Throat (2005), Roger Ebert wrote "Since the mob owned most of the porn theaters in the pre-video days and inflated box office receipts as a way of laundering income from drugs and prostitution, it is likely, in fact, that 'Deep Throat' did not really gross $600 million, although that might have been the box office tally."
In an interview, Amanda Seyfried talked about why she had no issue with being naked in this and other films. "I don't know why I'm comfortable. Nudity: whatever! Sex: we all do it. There's a time and a place to be naked (laughs). There's no part in this movie that makes me think, 'Oh, wow, she's naked.' She's a porn star! We simulated some scenes but there's no graphic content in this movie, at all. I mean the graphic stuff is when he's raping me on my wedding night. You see my skirt go up over my head when I'm being gang raped, but it's like so perfectly done. 'Chloe' is so graphic. And this is not...(Peter Sarsgaard and I) are not shy about our private parts. We also weren't walking around with our genitals out; our bottom half genitals. That might have been a little strange for me. I don't really have any interest in people seeing my vagina. It's just a personal thing. I don't mind seeing other people's vaginas. I guess I'm just insecure in that way. Peter, same thing. He was always covered up in that way. I think it's just our mutual understanding of we needed to be naked a lot of points in the movie and it wasn't a big deal. It's like a costume. I don't know why I feel comfortable. To be honest, when I was younger, I was terrified of sex. I don't know what happened over the years. I now have an appreciation for it, for people who don't put so much heaviness on it. I also don't understand why it's censored in movies."
Amanda Seyfried attended a screening of the film with her father, who was supportive of his daughter's work in the film and although Seyfried was uncomfortable with her father seeing her nude, she was happy to accompany him. She vowed to shield his eyes whenever her bare breasts were displayed.
In the simulated oral sex scenes, a Popsicle was used as a substitute for a penis.
Seyfried had to wear contacts and a wig for the role of Linda Lovelace, as Seyfried is a natural blonde with green eyes whereas Lovelace was dark haired and had brown eyes.