- Giulia Farnese: [Guilia finds Rodrigo unresponsive and quiet in bed] You find the art of politics more engrossing than...
- Rodrigo Borgia: Than the art of love?
- Giulia Farnese: Did I say that?
- Rodrigo Borgia: Hmmm, they have more in common than you would think.
- Ursula Bonadeo: [In bed] You make me hope, and I'm afraid of hope.
- Cesare Borgia: Hope for what?
- Ursula Bonadeo: For days like this in the future with you.
- Rodrigo Borgia: [Upset with Juan] Do you have any idea what lengths I've gone to to keep your mother's reputation intact?
- Rodrigo Borgia: [about the arranged marriage with his 13 year old son with the bastard daughter of the Neapolitan king and the dowry the Borgias will recieve] We need this union more than we need the riches. The wolves are bearing down on the Papal States.
- King Charles VIII: [to Della Rovere] Be careful what you pray for, Cardinal. You will find yourself in a place beyond prayer itself.