The audio under the opening credits is from a sketch Chapman regularly used to perform, where he asked a live audience at the start of the show to give him "thirty seconds of abuse", as this saved time later on. For this movie, specially recorded abuse was added from John Cleese, Sir Michael Palin, Terry Jones (shouting Medieval curse words), Terry Gilliam, Carol Cleveland, and David Sherlock, Chapman's former partner. One of the investors in this movie can also be heard shouting "I want my f**king money back!"
The scene where Graham is advised by (top British royal) The Queen Mother to go on a tour of New Zealand while at medical college actually happened in real-life. Animators drawing the sequence showed the Queen Mum wearing a wide hat and pale green dress. Subsequently, home movie footage emerged of her visit taken by Graham on the day, in which the Queen Mum is seen wearing an uncannily similar wide hat and pale green dress. The footage appears in the documentary which accompanies this movie, called "Anatomy of a Liar".
Eric Idle is the only Monty Python member not taking any part in this movie, although he is seen in an archive footage at the end.
In the scene where Graham is reading books in the car with his parents, his father takes the book and puts it in the glove compartment. In the glove compartment, are other confiscated books, and behind them a can of Spam. The Spam refers to the (in)famous "Spam" television sketch on Monty Python's Flying Circus (1969).