The first appearance of Vernee Watson as nurse Althea since The Werewolf Transformation (2012), where we also learn her full name from her badge (Althea Davis). It is also Watson's final appearance on the show, although she would later play a different nurse in the spin-off series Young Sheldon (2017).
Howard's mother's full name was Deborah (Debbie) Melvina Wolowitz.
This episode was taped on November 22, 2016.