The song became the album's signature track, reaching number 44 on Billboard Hot 100 Chart on 25 January 1992.
The track reached number 8 on the Mainstream Rock Chart on 19 October 1991.
An orchestral version of the song was recorded for the 2000s orchestral album Moment of Glory that features vocals split with Italian singer Zucchero.
An acoustic version of the song was recorded for the 2001's acoustic album Acoustica.
In 1994, the heavy metal band Black Sabbath, released the Cross Purposes studio album which contains the same burning angel in the design of the cover that the "Send Me an Angel" single has. Neither band has commented on the matter.