Notably two Robot Masters have different names in the Japanese version, which are Bounce Man whose Japanese name is Rubber Man and Impact Man whose Japanese name is Pile Man.
This is the first game from the Classic Mega Man series since Mega Man 8 (1996) to include full voice acting.
Both this game as well as the earlier 2018 dual release of Rockman X Anniversary Collection (2018) (VG) and Rockman X Anniversary Collection 2 (2018) (VG) celebrate the 30th Anniversary of the Mega Man franchise.
In the Japanese title the words "Unmei no Hagurum" translates as "Gears of Fate'', in reference to the Double Gear system, which is a new gameplay option that is used in the game.
One of Block Man's defeat quotes, "You Blockhead!" is a reference to the comic strip, Peanuts.