- Dr. John Sturgis: It was my dream to win the Nobel, and I'm not going to. I bet Sheldon will.
- Meemaw: [Chuckles] That'll be somethin'.
- Dr. John Sturgis: Yeah.
- Missy Cooper: You know what I like about you, Sheldon? You're incredibly smart, but you're also really dumb.
- Sheldon Cooper: Why would you say that?
- Missy Cooper: You think people are gonna come here to hang out with you?
- Sheldon Cooper: Yes.
- Missy Cooper: To hear about science?
- Sheldon Cooper: Yes.
- Missy Cooper: On the radio?
- Sheldon Cooper: Yes.
- Missy Cooper: At 5:00 in the morning?
- Sheldon Cooper: Yes.
- Missy Cooper: And you're asking me why you're dumb?
- Sheldon Cooper: Well, I happen to have a little more faith in the curiosity of my fellows.
- Missy Cooper: See, you sound smart, but you're still dumb.
- Sheldon Cooper: [Voiceover] A primary feature of quarks is that they're always bonded together, but in that moment, I felt like a neutrino, destined to be alone forever.
- [Flashes through montage over young Big Bang Theory characters]
- Sheldon Cooper: Thankfully, I was wrong.