'Familia Blondina' revolves around Cindy, a woman who leaves her family and moves to the US to marry an American soldier. They have three children, all blonde. When the American husband dies, he leaves her in debt and she must return to the Philippines with her children. She goes through a series of misadventures looking for a job and she meets Tony Boy (Jobert Austria, aka Kuya Jobert), a widower father of two blond children. Together, they become a blended family, raising their children on what being Filipino.