40-year best friends, co-workers and sisters-in-law, make it out of their British working class neighborhood for a fantasy trip to Las Vegas, tempered by the fact that one of them is dying. Director Nick Hurran and writer Kay Mellor combine quite a number of different ingredients here (including illness, men-vs.-women, factory life, family problems, financial windfalls, travelogue and lovestruck cowboys); and yet, despite some missteps, this weeper from the UK is a worthwhile journey anchored by terrific performances. Playing the firebrand and ill-tempered man-chaser, Julie Walters tones down her sometimes-brash personality and has several beautifully realized moments. As her "mate", Brenda Blethyn juggles the more standardized clichés of a character with a limited amount of time left (she's brave, she glows, she's suddenly strong and charts her own course); however, Blethyn is very engaging and works so naturally and easily with Walters that their friendship strikes nary a false note. Hurran's dreamy framing of this story, with a puzzling introduction, may put some viewers off, but those who stick with it will find a rewarding drama about friendship and love. These themes have been touched on before in films--and true, there isn't much originality or surprises in Mellor's script--yet the bumps in the road are actually rather endearing, and by the end of "Girls' Night" I was moved by the thoughtfully worked-out transition of the plotting. It's a minor gem. *** from ****