Billy Caufield (Michael Keaton) is a delusional writer with anger issues. Henry Sikorsky (Christopher Lloyd) avoids his family and pretends to be a doctor. Jack McDermott (Peter Boyle) is the religious former ad exec who likes to walk around naked. Albert Ianuzzi (Stephen Furst) has trouble communicating. Dr. Weitzman (Dennis Boutsikaris) is treating them at Cedarbrook Hospital. He takes them on a field trip to the Yankees game. Albert pretends to pee and makes a run for it. Weitzman goes looking for him and stumbles upon a murder. He is knocked unconscious and hospitalized while his patients are left on their own. Billy reconnects with girlfriend Riley (Lorraine Bracco). The guys discover that two corrupt cops (Philip Bosco, James Remar) are trying to kill Weitzman but nobody believes the four runaway mental patients.
The four leads are a fun group of comedic actors. This is set up for a hilarious irreverent road trip. It doesn't always come together but there is some fun to be had. The writing is not that sharp but the guys are able to pull out a few laughs. After Weitzman is taken to the hospital, the guys split up for about fifteen minutes. That's not the best idea since building up their fun chemistry is half the battle. The cast's full potential is never fully realized.
The four leads are a fun group of comedic actors. This is set up for a hilarious irreverent road trip. It doesn't always come together but there is some fun to be had. The writing is not that sharp but the guys are able to pull out a few laughs. After Weitzman is taken to the hospital, the guys split up for about fifteen minutes. That's not the best idea since building up their fun chemistry is half the battle. The cast's full potential is never fully realized.