For me, the beginning of the season 4 is probably one of the best sets of episodes for M.D. House (a good sets is the ones with the detective in a previous season).
Here, House is really in free wheel, nothing to stop him, he is an absolute jerk without constraints or limits and it is funny, witty and ... well I must admit, absolutly without moral. About the medical case, it is so human... it does give a good balance to our favorite sociopath.