According to the series pilot, the character 'Six' was named because of the number of beers her parents drank the night of Six's conception. This minutiae was downplayed later in the series, referring to her birth order instead.
This was the last series Ted Wass acted in and the first he directed.
Jada Pinkett Smith auditioned for, and landed, the role of Six Lemeure but reneged in the end feeling she'd be miserable, at age 18, playing a 12-year-old.
One notable guest star was David Schwimmer, who played Six's older boyfriend, Sonny, shortly before Schwimmer found success as Ross Geller on "Friends."
Although the show's original concept was for Blossom to have a hip, single musician dad, the executives insisted she has two parents in the pilot. However, after a great deal of fighting with show producers, the network caved, and the show went back to the original idea, casting Ted Wass as Blossom's single musician dad.